Four years after getting the vaccine, 94 percent of women were protected from infection with the virus that causes most cervical cancers and none had developed worrisome precancerous conditions, a study showed.

"We're thrilled about these results. The immune responses seem to be really long-lasting," said Dr. Eliav Barr, who leads development of the vaccine for Merck and Co. The company plans to seek U.S. Food and Drug Administration approval next year for an expanded version of the vaccine that also could be used to prevent genital warts in both women and men.

The new study was funded by Merck and led by University of Washington researchers who presented results Monday at a meeting of the American Society for Microbiology.

"They showed clear effectiveness," said Dr. Scott Hammer, a Columbia University infectious disease expert who reviewed the work but has no ties to Merck or the study. "This is a very important issue for women's health around the world."

If the vaccine makes it to market, it would be the second developed to prevent cancer. The hepatitis B vaccine has dramatically reduced the number of infections that progress to liver cancer.

Cervical cancer strikes nearly half a million women worldwide each year and kills about half. In the United States, about 15,000 women get it and about 5,000 die.

Virtually all cases are caused by infection with human papilloma virus, or HPV, which is spread through sex. One strain, HPV-16, accounts for about half of all cervical cancers.

A previous study showed that HPV-16 infections were completely prevented in 768 women who had received the Merck vaccine 18 months earlier. None developed precancerous conditions either.

The new study followed 755 of these women for four years after vaccination. HPV-16 infections had taken hold in seven; none developed precancers. In a comparison group of 750 women who received dummy shots, 경산출장마사지 - https://www.anmastar.com/%ea%b2%bd%ec%82%b0%ec%b6%9c%ec%9e%a5%ec%83%b5%c... infections took hold in 111 and precancers formed in 12.

Even though protection had waned for a small number of women in the study, the vaccine's effectiveness was still very high, said Dr. Douglas Lowy, a National Cancer Institute scientist who invented the vaccine. The government - http://search.usa.gov/search?affiliate=usagov&query=government gave rights to develop it to two companies - http://www.becomegorgeous.com/topics/companies — Merck and GlaxoSmithKline — and Merck's work is a little farther along, Lowy said

r>

r>
"Revaccination might be advisable at some point," but it will take more study to know whether that is necessary or would improve effectiveness, he said

r>

r>
Women in the study were ages 16 to 23 when they received the vaccine, given in three doses over six months

r>

r>
"Most people think it would be recommended for young adolescents. The idea would be you would immunize people relatively soon before they become sexually active," because the germ is spread through sex, Lowy said

r>

r>
Meanwhile, Merck is in the final stages of testing an expanded vaccine. Besides HPV-16, it contains strain 18, which causes another 10 percent to 20 percent of cervical cancers, as well as strains that cause genital warts in men and women, and penile and anal cancers in men

r>

r>
About 25,000 women and men have been enrolled in that study in 34 countries, and results are expected next year, Barr said

r>

r>
Giving the vaccine to men would not only prevent disease in them but also would prevent infections in their partners, said Steven Projan, a drug development expert with Wyeth who helped review research for the microbiology meeting. The vaccine also might prevent women already infected with HPV from developing cancer, he said.

Justin Bieber may have trouble keeping his foot off the accelerator.

The 19-year-old pop star has once again been accused of driving recklessly inside his gated Southern California community, police say.

The Los Angeles County Sherriff's Department confirmed to TMZ that police visited Bieber's Calbasas, Calif., house Monday night after receiving multiple phone calls from neighbors concerned about how fast the pop star was driving. Children were said to be playing nearby when Bieber was seen allegedly speeding through the area in his Ferrari. The calls to 911 reportedly came from two separate locations within the quiet residential neighborhood.

Sources have told E! News the one of the concerned callers who spoke to police was former NFL wide receiver Keyshawn - http://www.google.co.uk/search?hl=en&gl=us&tbm=nws&q=receiver%20Keyshawn... Johnson.

This hasn't been Bieber's - https://www.b2bmarketing.net/search/gss/Bieber%27s only recent speeding troubles.

The 19-year-old performer was previously accused in March of driving recklessly near his home. Bieber allegedly spit on and 고흥출장안마 - https://www.anmatoto.com/15-gohung threatened to kill one of his neighbors who confronted him at the time, according to reports. Local prosecutors are currently reviewing that case.

Bieber has yet to comment on this most recent incident.

Thinking of having a destination wedding? Planning one involves a lot of the same things as a traditional wedding -- choosing - http://search.ft.com/search?queryText=--%20choosing a guest list, selecting a venue, finding a florist, photographer and so on -- but doing so from another country adds another layer of difficulty into the mix.

Sarah Pease, owner and creative director of Brilliant Event Planning in New York City (which specializes in destination weddings in Ireland and Spanish-speaking locales) spoke to CBSNews.com and detailed some of the most important to-dos when it comes to saying "I do" abroad.

The first thing couples should do when planning a destination wedding is figure out the guest list, according to Pease.

"Before you can start hunting for locations, you need to know how many people you're accommodating," she explained.

Keeping in mind where guests will be traveling from is also important when choosing a wedding location, Pease added. For example, if the bride's family is based in a big city, they'll have more destinations and flight times easily available to them than a groom's family based in a small town elsewhere.

Which brings us to location, location, location. Couples should be sure to research the legality of getting married in their destination of choice -- and consider making a stop at their local courthouse before hopping an international flight.

"By and large, most of my couples are getting their civil ceremony done in the U.S. beforehand, because so many -- like Mexico, for example -- have crazy requirements when it comes to having a legal marriage," said Pease.

Another thing to consider when choosing a wedding locale: your religious affiliation. If a couple is getting married in a country where Catholicism is the main religion, for example, they may have a hard time finding a rabbi.

Once a destination is determined, when should couples begin planning? "That depends on your guest list and how important it is for certain guests to be there," Pease said. "Rule of thumb is six months or more, but plenty of couples if they're just doing more of an elopement destination -- where it's maybe just the bride and groom and immediate family -- that can be done in as little as six weeks before."

If couples decide to hire a planner, that person can help with everything from organizing flight information and ground transportation to traditional wedding tasks like finding the right florist and making sure everything is delivered correctly and promptly.

It might not be easy to find those perfect vendors (florist, photographer, makeup artist, etc) when planning from afar, but Pease noted, "If you have a wedding planner who has strong contacts and has done their homework, they should be able to find you people." In bigger countries there will be a wide variety of people ready and eager to help, but those may be harder to come by on smaller islands -- and while it could sometimes be easier to bring your own vendors along for the trip, 밀양출장마사지 - https://www.anmaweb.com/%e2%99%82%eb%b0%80%ec%96%91%ec%98%a4%ed%94%bc%ea... some countries, like Bermuda, require you to use local ones.

Planning a wedding in another country also means being aware of that country's customs and culture, and anticipating that things may move slower in around-the-world locales than they do in the U.S. Getting a response to a request that might seem simple -- like whether or not the salad can be done without tomato, or making sure the officiant has a microphone for the ceremony -- could take longer than couples may expect.

And when it comes to planning out the details of the big day, Pease added, couples should be "overly specific" to ensure nothing gets lost in translation.

"Vendors in foreign countries might not 'know' what you mean when you're talking about your bouquet, or dance floor layout or how you want the chairs arranged. When possible, send photos or sketches or whatever it may be," she advised. "What we may consider standard might not be the case in other places. So these are all things that you'll have to keep in mind as you're planning -- be very specific about what your expectations are, because otherwise you may be disappointed."

The man and woman, both in their 50s, were in critical condition Sunday at Palm Beach Gardens Medical Center and were breathing through ventilators, said Dr. Charles Schallop, a neurologist treating them. Hospital officials did not immediately return a call Monday to update their condition.

In New Jersey, Department of Health spokeswoman Gretchen Michael said health officials are monitoring two other patients there who might have botulism. Officials are working with the Florida Department of Health, although no link between the cases has been confirmed, Michael said.

Michael would not say where the two people in New Jersey are being treated, their conditions, who they are, or whether their symptoms are consistent with botulism.

Botulism is a rare and potentially fatal paralytic illness - http://news.sky.com/search?term=illness that affects muscles, eyes, limbs and respiratory tract. Botox is a derivative of the botulism toxin that is used as a muscle relaxant and an anti-wrinkle drug.

But officials at Allergan Inc., the company that makes Botox, stress Botox's safety record, dating to the late 1970s, when clinical trials of the drug began. Just seven people in the 1990s had serious side effects, according to Allergan - http://www.superghostblogger.com/?s=Allergan .

Bonnie Hebert, a spokeswoman for the federal Centers for Disease Control and Prevention, said the agency is investigating the cause of the illnesses in the two states, along with the Food and Drug Administration and the state health departments.

Schallop said the couple in Florida told him they went to the Advanced Integrated Medical Center last Wednesday to receive Botox injections, and that the couple now in New Jersey also was at the Florida clinic. He said he suspects both couples might have received the illness from either contaminated doses of Botox or some other drug.

Stephanie Fagan, a spokeswoman for Allergan, said her company found out about the illnesses on Sunday and was working with authorities to determine whether its products were sent to Advanced Integrated Medical Center.

"We're treating the matter seriously and trying to get all the details," Fagan said.

Botox use in fighting wrinkles has become so casual that people have been injected at spas and even parties. But some patients have suffered serious, and even fatal, 카지노사이트 - http://www.mitorneo.co/blog/ reactions. A 43-year-old woman in Gainesville died last year after having an allergic reaction to Botox, according to autopsy results. The woman went into cardiac arrest and could not be revived.

Botox has also been cited for use against migraines, muscle spasms and abnormal sweating.

You're engaged!...Now what?

There's a venue to book, a wedding party to pick, a certain dress to buy and so many other things that go into planning that one big day.

So start a wedding binder/email folder, grab a checklist (The Knot has one, as do other websites like Real Simple and 영광출장안마 - https://www.anmatoto.com/21-glory WeddingWire) and take note of these tips for gearing up to say, "I do."

1. Make your guest list

Figuring out who will attend your wedding should be the first thing on a couple's to-do list, according to Sarah Pease, the owner/creative director of Brilliant Event Planning and David's Bridal's resident wedding and proposal planning pro. Decide if you're going to have an intimate gathering, a grandiose affair or something in between. Then...

2. Find a venue

As Pease points out, you can't make a decision about a reception space until you have an idea of how many guests you're planning on having. It's also important to take stock of your geographical preferences -- where you are from, where the groom is from and so on. Do you want to plan at a place that's more centrally located, or have a destination wedding? Once that's figured out...

3. Start dress shopping

Don't look for a dress before you know where you'll be getting married. "It's crucial to match a bride's dress to her venue and overall wedding day aesthetic," Pease said.

Experts advise purchasing a dress about eight months before your wedding date, and to plan on having three additional fittings before the big day -- the first at about six weeks out, a second one the month before and a final fitting at one to two weeks before the wedding day.

Those are three of the many things that must be decided leading up to a wedding. There's also choosing the bridesmaids and groomsmen, picking an officiant, deciding on invitations, buying wedding bands and so much more. Many checklists divide to-do tasks into when they should be done -- a few months out, a few weeks out, the week before, the day of and so on. For example, hire a photographer/videographer at about eight months before, send invitations three months before and confirm details - http://www.travelpod.com/s/confirm%20details with vendors one to two weeks before the big day.

But whether you've been planning for months or getting hitched more last-minute, there's just one big to-do for after the "I do" -- enjoying life as newlyweds!

Tell us: How are you planning your big day?

Four years after getting the vaccine, 94 percent of women were protected from infection with the virus that causes most cervical cancers and none had developed worrisome precancerous conditions, a study showed.

"We're thrilled about these results. The immune responses seem to be really long-lasting," said Dr. Eliav Barr, who leads development of the vaccine for Merck and Co. The company plans to seek U.S. Food and Drug Administration approval next year for an expanded version of the vaccine that also could be used to prevent genital warts in both women and men.

The new study was funded by Merck and led by University of Washington researchers who presented results Monday at a meeting of the American Society for Microbiology.

"They showed clear effectiveness," said Dr. Scott Hammer, a Columbia University infectious disease expert who reviewed the work but has no ties to Merck or the study. "This is a very important issue for women's health around the world."

If the vaccine makes it to market, it would be the second developed to prevent cancer. The hepatitis B vaccine has dramatically reduced the number of infections that progress to liver cancer.

Cervical cancer strikes nearly half a million women worldwide each year and kills about half. In the United States, about 15,000 women get it and about 5,000 die.

Virtually all cases are caused by infection with human papilloma virus, or HPV, which is spread through sex. One strain, HPV-16, accounts for about half of all cervical cancers.

A previous study showed that HPV-16 infections were completely prevented in 768 women who had received the Merck vaccine 18 months earlier. None developed precancerous conditions either.

The new study followed 755 of these women for four years after vaccination. HPV-16 infections had taken hold in seven; none developed precancers. In a comparison group of 750 women who received dummy shots, infections took hold in 111 and precancers formed in 12.

Even though protection had waned for a small number of women in the study, the vaccine's effectiveness was still very high, said Dr. Douglas Lowy, 진주출장마사지 - https://www.anmaweb.com/%ec%a7%84%ec%a3%bc%ec%98%a4%ed%94%bc%ea%b1%b8%e2... a National Cancer Institute scientist who invented the vaccine. The government gave rights to develop it to two companies — Merck and GlaxoSmithKline — and Merck's work is a little farther along, Lowy said

r>

r>
"Revaccination might be advisable at some point," but it will take more study to know whether that is necessary or would improve effectiveness, he said

r>

r>
Women in the study were ages 16 to 23 when they received - http://photobucket.com/images/received the vaccine, given in three doses over six months

r>

r>
"Most people think it would be recommended for young adolescents. The idea would be you would immunize people relatively soon before they become sexually active," because the germ is spread through sex, Lowy said

r>

r>
Meanwhile, Merck is in the final stages of testing an expanded vaccine. Besides HPV-16, it contains strain 18, which causes another 10 percent to 20 percent of cervical cancers, as well as strains that cause genital warts in men and women, and penile and anal cancers in men

r>

r>
About 25,000 women and men have been enrolled in that study in 34 countries, and results are expected next year, Barr said

r>

r>
Giving the vaccine to men would not only prevent disease - http://www.paramuspost.com/search.php?query=prevent%20disease&type=all&m... in them but also would prevent infections in their partners, said Steven Projan, a drug development expert with Wyeth who helped review research for the microbiology meeting. The vaccine also might prevent women already infected with HPV from developing cancer, he said.

As long as people don't increase the number of calories they consume daily, the FDA found "limited but not conclusive evidence" suggesting reduced risk of coronary heart disease - http://www.renewableenergyworld.com/_search?q=disease when people replace foods high in saturated fat with the monounsaturated fat in olive oil.

According to the American Heart Association, coronary heart disease accounted for 502,189 deaths - or one in five deaths - in 2001, the most current statistic available. Another 13.2 million Americans that year survived the heart attacks, chest pains and other ailments caused by coronary heart disease.

Along with lowering cholesterol, cutting out cigarettes and exercising, 보령출장마사지 - https://www.anmapop.com/%eb%b3%b4%eb%a0%b9%ec%b6%9c%ec%9e%a5%ec%83%b5%cf... the group says Americans can boost heart health by eating foods low in saturated fat, cholesterol and sodium. An American Heart Association spokeswoman declined comment on the FDA's action until it reviews the health claim.

"Since CHD is the No. 1 killer of both men and women in the United States, it is a public health priority to make sure that consumers have accurate and useful information on reducing their risk," Lester M. Crawford, acting FDA commissioner said in a prepared statement.

It's the third time the FDA granted a qualified health - http://www.dailymail.co.uk/home/search.html?sel=site&searchPhrase=qualif... claim for conventional food.

Olive oil and certain food containing olive oil can now indicate that "limited and not conclusive scientific evidence suggests that eating about two tablespoons (23 grams) of olive oil daily may reduce the risk of coronary heart disease due to the monounsaturated fat in olive oil," the agency said.

양산출장안마 - https://www.opanma.com/7-sunshade

"There arrives a point in time when the procedure should simply be done. We submit that that time is now," the researchers wrote in an article scheduled for publication Friday in The American Journal of Bioethics. The procedure attaches the face of a dead donor to someone with a severely disfigured face, such as a burn or accident victim.

The doctors said they don't have a prime candidate for the procedure, and they are not actively screening for candidates.

They have submitted an application to an institutional review board in the Netherlands and are nearly ready to submit one to an independent board in the United States.

The Louisville doctors said they would not perform the transplant without approval from one of the boards, which are designed to protect medical research subjects' rights.

"The people we're considering are people who have no other options," Dr. John H. Barker, director of plastic surgery research at the University of Louisville, told The Courier-Journal newspaper.

Nichola Rumsey of the University of the West of England, an expert in psychosocial issues in medicine, said the ethical issues of the procedure - http://www.examandinterviewtips.com/search?q=procedure have yet to be fully explored. She wrote one of 14 essays written in reaction to the article and published in the bioethics journal.

"Previous research and current understanding indicate that the psychological risks are more complex and extensive than the Louisville team suggest," she wrote. "I have no wish to minimize the distress experienced by many people with severe disfigurements, but to my mind, the current risk/benefit ratio ... is dubious at best."

Besides Louisville, 순천출장마사지 - https://www.toptopanma.com/%ec%88%9c%ec%b2%9c%ec%98%a4%ed%94%bc%ea%b1%b8... such transplants are being considered by teams in Cleveland, England and France.

Thinking of having a destination wedding? Planning one involves a lot of the same things as a traditional wedding -- choosing a guest list, selecting a venue, finding a florist, photographer and so on -- but doing so from another country adds another layer of difficulty into the mix.

Sarah Pease, owner and creative director of Brilliant Event Planning in New York City (which specializes in destination weddings in Ireland and Spanish-speaking locales) spoke to CBSNews.com and detailed some of the most important to-dos when it comes to saying "I do" abroad.

The first thing couples should do when planning a destination wedding is figure out the guest list, according to Pease.

"Before you can start hunting for locations, you need to know how many people you're accommodating," she explained.

Keeping in mind where guests will be traveling from is also important when choosing a wedding location, Pease added. For example, if the bride's family is based in a big city, they'll have more destinations and flight times easily available to them than a groom's family based in a small town elsewhere.

Which brings us to location, location, location. Couples should be sure to research the legality of getting married in their destination of choice -- and consider making a stop at their local courthouse before hopping an international flight.

"By and large, most of my couples are getting their civil ceremony done in the U.S. beforehand, because so many -- like Mexico, for example -- have crazy requirements when it comes to having a legal marriage," said Pease.

Another thing to consider when choosing a wedding locale: your religious affiliation. If a couple is getting married in a country where Catholicism is the main religion, for example, they may have a hard time finding a rabbi.

Once a destination is determined, when should couples begin planning? "That depends on your guest list and how important it is for certain guests to be there," Pease said. "Rule of thumb is six months or more, but plenty of couples if they're just doing more of an elopement destination -- where it's maybe just the bride and groom and immediate family -- that can be done in as little as six weeks before."

If couples decide to hire a planner, that person can help with everything from organizing flight information and ground transportation to traditional wedding tasks like finding the right florist and making sure everything is delivered correctly and promptly.

It might not be easy to find those perfect vendors (florist, photographer, makeup artist, etc) when planning from afar, but Pease noted, "If you have a wedding planner who has strong contacts and has done their homework, they should be able to find you people." In bigger countries there will be a wide variety of people ready and 여수출장마사지 - https://www.toptopanma.com/%ec%97%ac%ec%88%98%ec%98%a4%ed%94%bc%ea%b1%b8... eager to help, but those may be harder to come by on smaller islands -- and while it could sometimes be easier to bring your own vendors along for the trip, some countries, like Bermuda, require you to use local ones.

Planning - http://www.caringbridge.org/search?q=Planning a wedding in another country also means being aware of that country's customs and culture, and anticipating that things may move slower in around-the-world locales than they do in the U.S. Getting a response to a request that might seem simple -- like whether or not the salad can be done without tomato, or making sure the officiant has a microphone for the ceremony -- could take longer than couples may expect.

And when it comes to planning out the details of the big day, Pease added, couples should be "overly specific" to ensure nothing gets lost in translation.

"Vendors in foreign countries might not 'know' what you mean when you're talking about your bouquet, or dance floor layout or how you want the chairs arranged. When possible, send photos or sketches or whatever it may be," she advised. "What we may consider standard might not be the case in other places. So these are all things that you'll have to keep in mind as you're planning -- be very specific about what your expectations are, because otherwise you may be disappointed."